Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals
نویسندگان
چکیده
منابع مشابه
Signaling death via inositol pyrophosphates
Inositol polyphosphates mediate a myriad of cell signaling reactions, and, during the past decade, a novel molecule class known as inositol pyrophosphates has been identified. These molecules contain energetic pyrophosphate bonds. Adolfo Saiardi et al. previously found that the inositol pyrophosphate diphosphoinositol-pentakisphosphate (IP7) transfers one of its phosphate moieties to target pro...
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The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established. Using several yeast mutants with defects in inositol phosphate metabolism, we identify dramatic membrane defects selectively ...
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Myo-inositol is present in nature either unmodified or in more complex phosphorylated derivates. Of the latest, the two most abundant in eukaryotic cells are inositol pentakisphosphate (IP(5;)) and inositol hexakisphosphate (phytic acid or IP(6;)). IP(5;) and IP(6;) are the precursors of inositol pyrophosphate molecules that contain one or more pyrophosphate bonds(1). Phosphorylation of IP(6;) ...
متن کاملInositol pyrophosphates: between signalling and metabolism.
The present review will explore the insights gained into inositol pyrophosphates in the 20 years since their discovery in 1993. These molecules are defined by the presence of the characteristic 'high energy' pyrophosphate moiety and can be found ubiquitously in eukaryotic cells. The enzymes that synthesize them are similarly well distributed and can be found encoded in any eukaryote genome. Rap...
متن کاملInositol pyrophosphates regulate JMJD2C-dependent histone demethylation.
Epigenetic modifications of chromatin represent a fundamental mechanism by which eukaryotic cells adapt their transcriptional response to developmental and environmental cues. Although an increasing number of molecules have been linked to epigenetic changes, the intracellular pathways that lead to their activation/repression have just begun to be characterized. Here, we demonstrate that inosito...
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ژورنال
عنوان ژورنال: Molecules
سال: 2020
ISSN: 1420-3049
DOI: 10.3390/molecules25092208